Models of manufacturing and production processes can provide value through the lifecycle of these facilities, from up front design through ongoing personnel training and optimization. One quick example is the simulation used to test out the control strategies before commissioning the control system.
In a BioPharm International article, Biopharma modeling, now and five years from now, Emerson’s Bob Lenich describes some key applications where biopharmaceutical manufacturers create value through the models they create and use.
When asked for the 3 most important applications for process modeling, Bob responded:
In development, we are seeing greater use of modeling in quality parameter optimization, continuous yield improvement, and facility design and fit.
In running processes, he noted:
‘Soft-sensor’ correlations and converting spectral data to the required process value are examples of using models to generate key quality attribute data in real time.
For ongoing optimization:
…having a digital twin model of the unit operation facilitates yield optimization of individual pieces of equipment and the overall process. A medium-to-high-fidelity process model allows development of the required automation for the production process to proceed off-line and as new equipment is added to ensure proper process control.
Also, having these digital twin simulations:
…allows bottlenecks to be identified and addressed to ensure optimal facility performance. For instance, organizations can utilize a digital twin to perform engineering runs during product change-over in a digital environment to prove out the process and automation before going to live production.
Read the article for Bob’s thoughts when asked about what the future in five years holds and Life Science manufacturers resistance to developing and using models.
Visit the Life Sciences & Medical section on Emerson.com for more on the automation expertise & technology to help regulated manufacturers increase operating efficiency and optimize production. You can also connect and interact with other pharmaceutical and biotech industry experts in the Life Sciences group in the Emerson Exchange 365 community.
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