Clean-in-Place (CIP) is central to the manufacturing processes of the biotech and pharmaceutical industries and conductivity analysis is central to the successful operation of CIP. This point was made in a recent article in Asia Pacific Biotech News by Ryo Hashimoto, senior manager, liquid analytical & combustion instruments, at Emerson Automation Solutions, Asia Pacific. Ryo states, “Conductivity measurement is so integral to the pharmaceutical manufacturing process that it is easy to take for granted. However, understanding some basics of its operation and correct application can make a big difference in the effectiveness and efficiency of CIP.”
In the article, Ryo explains, “By measuring conductivity, plants can determine the interface between cleaning solutions and rinse water. When the conductivity drops to the value of rinse water, it indicates the next step in the cycle can begin. This minimizes CIP time while enabling regulatory compliance. Conductivity is also an effective way to detect the interface between the cleaning solutions and the product, so that valves can be switched at the right time to prevent cross-contamination and product loss.”
The article then goes on to explore some of the trickier aspects of conductivity measurement such as the impact of temperature on conductivity and the best approach to calibration of conductivity sensors. If you use CIP in your operations, Ryo’s article will make an excellent contribution to effective and efficient operation.
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Posted by Deanna Johnson, Rosemount Measurement & Analytical Global Marcom Manager, Emerson Automation Solutions